The Vogue hitmaker's elder brother Anthony Ciccone has been living on the streets of Traverse City, Michigan for almost three years after losing his job at the family's vineyard.
Madonna previously tried to help her sibling with his alcohol battle by paying for him to attend a rehab clinic in Texas eight years ago, but the treatment was unsuccessful and reports suggest Ciccone recently spent a month in jail for public intoxication and swearing in front of children.
Hitting out at his superstar sibling, whose net worth was this week estimated at $1 billion, Ciccone tells the MailOnline.co.uk, "Madonna doesn't give a s**t if I'm dead or alive. She lives in her own world. I never loved her in the first place, she never loved me. We never loved each other.
"(I am in this position because I had) no family back-up, when the chips fell, no family back-up. I'd rather be working. What would you do under these circumstance when your family has stood against you completely?"
But Kathy Mateyer, a close friend of the family who works in the vineyard's winetasting room, claims both Madonna and her father Tony have tried to reach out to her brother several times - to no avail.
She tells the publication, "They have helped him so many times. Tony has put him through rehab and given him lots of chances. I think Madonna paid for rehab a few times."